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The most basic question to ask is "What is HIV pre-exposure prophylaxis (PrEP)?"
Pre-exposure prophylaxis is any treatment you take to prevent catching a disease before you get exposure to it. So, you take this treatment to prevent catching an HIV infection, before you get exposure to the virus. This treatment protocol uses antiretroviral drugs used in treating HIV infections. The drugs that researchers are testing are tenofovir and emtricitabine in a combined tablet. Studies, done in animal models, demonstrated that this combination was very effective for preventing infection. A human trial performed last year also demonstrated that this combination was able to cut down on potential infections. The average reduction was 42 per cent (range: 15 to 65 per cent according to cases).
What is required for HIV pre-exposure prophylaxis (PrEP) to work effectively?
One difference between animal and human studies is the fact that human beings are not in cages and closely monitored. The human trials involve giving the medications to high-risk groups and having them report for testing every few weeks. Test subjects who stuck with the drug protocol closely had more protection than those that did not follow the protocol closely. So, in order for this to work, those taking the drugs must closely follow protocols in order to get the most effect from it. They were also advised to systematically use condoms, and these prevention measures were assessed and repeated at each protocol visit.
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